A trans fatty acid
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Elaidic Acid

Item No. 90250

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9E-octadecenoic acid
CAS Number
112-79-8
Synonyms
  • C18:1(9E)
  • FA 18:1
  • 9(E)-Oleic Acid
  • trans-Oleic Acid
Molecular Formula
C18H34O2
Formula Weight
282.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
0.15 M Tris-HCl pH 8.5: 1 mg/mlDMF: 100 mg/mlDMSO: 100 mg/mlEthanol: 100 mg/ml
SMILES
CCCCCCCC/C=C/CCCCCCCC(=O)O
InChi Code
InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h9-10H,2-8,11-17H2,1H3,(H,19,20)/b10-9+
InChi Key
ZQPPMHVWECSIRJ-MDZDMXLPSA-N
Side Chain Carbon Sum
18:1
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    50 mg

    $21

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    100 mg

    $33

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    250 mg

    $69

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    1 g

    $105

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    Product Description

    Elaidic acid is a monounsaturated trans fatty acid and the 9-trans isomer of oleic acid (Item Nos. 90260 | 24659) that has been found in partially hydrogenated cooking oils.1 It reduces HHT and HETE formation and increases synthesis of prostaglandin E2 (PGE2; Item No. 14010), PGF2α (Item Nos. 16010 | 16020), PGD2 (Item No. 12010), and thromboxane B2 (TXB2; Item No. 19030) induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in isolated human platelets. Elaidic acid (0.1-5 mmol/L) induces apoptosis in human umbilical vein endothelial cells (HUVECs).2 In vivo, elaidic acid (100 mg/kg) reduces cardiac and hepatic autophagy induced by palmitic acid (Item No. 10006627) in mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Srivastava, K.C., and Awasthi, K.K. A comparative study on the effect of cis (oleic, linoleic) and trans (elaidic, linoelaidic) fatty acids on the in vitro prostaglandin biosynthesis in human blood platelets from (1-14C) arachidonic acid. Prostaglandins Leukot. Med. 9(6), 669-684 (1982).

    2. Zapolska-Downar, D., Kośmider, A., and Naruszewicz, M. Trans fatty acids induce apoptosis in human endothelial cells. J. Physiol. Pharmacol. 56(4), 611-625 (2005).

    3. Sauvat, A., Chen, G., Müller, K., et al. Trans-fats inhibit autophagy induced by saturated fatty acids. EBioMedicine 30, 261-272 (2018).

    Product Citations

    Magtanong, L., Ko, P.-J., To, M., et al. Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state. Cell Chem. Biol. 26(3), 420-432 (2019).

    Yamamoto, T., Matsui, H., Yamaji, K., et al. Narrow-spectrum inhibitors targeting an alternative menaquinone biosynthetic pathway of Helicobacter pylori. J. Infect. Chemother. 22(9), 587-595 (2016).