An Analytical Reference Material
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  • This product is qualified as a Reference Material that has been manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards
  • This product is intended to be used as an analytical reference standard
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Buprenorphine (hydrochloride)

Item No. 14025

Restricted Product (Schedule III)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • CL 112,302
  • NIH 8805
Technical Information
Formal Name
(αS,5α,7α)-17-(cyclopropylmethyl)-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α-methyl-6,14-ethenomorphinan-7-methanol, monohydrochloride
CAS Number
53152-21-9
Molecular Formula
C29H41NO4 • HCl
Formula Weight
504.1
Purity
≥98%
Formulation
A neat solid
SMILES
CO[C@@]1(CC2)[C@@](OC3=C4C5=CC=C3O)([H])[C@@]4(CCN(CC6CC6)[C@]7([H])C5)[C@@]27C[C@]1([H])[C@](C)(O)C(C)(C)C.Cl
InChi Code
InChI=1S/C29H41NO4.ClH/c1-25(2,3)26(4,32)20-15-27-10-11-29(20,33-5)24-28(27)12-13-30(16-17-6-7-17)21(27)14-18-8-9-19(31)23(34-24)22(18)28;/h8-9,17,20-21,24,31-32H,6-7,10-16H2,1-5H3;1H/t20-,21-,24-,26+,27-,28+,29-;/m1./s1
InChi Key
UAIXRPCCYXNJMQ-RZIPZOSSSA-N
Regulatory Information
DEA Schedule
III
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Buprenorphine (hydrochloride) (Item No. 14025) is an analytical reference material that is structurally classified as an opioid. It is a partial agonist of the µ-opioid receptor (Ki = 4.18 nM) that less potently acts at δ- and κ-opioid receptors (Kis = 25.8 and 12.9 nM, respectively).1,2 Buprenorphine is used, alone or with naloxone (Item Nos. ISO60191 | 15594), to counter opiate addiction.3,4 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bart, G. Maintenance medication for opiate addiction: The foundation of recovery. J. Addict. Dis. 31(3), 207-225 (2012).

    2. Codd, E.E., Shank, R.P., Schupsky, J.J., et al. Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: Structural determinants and role in antinociception. J. Pharmacol. Exp. Ther. 274(3), 1263-1270 (1995).

    3. Tetrault, J.M., and Fiellin, D.A. Current and potential pharmacological treatment options for maintenance therapy in opioid-dependent individuals. Drugs 72(2), 217-228 (2012).

    4. Chen, K.Y., Chen, L., and Mao, J. Buprenorphine-naloxone therapy in pain management. Anesthesiology 120(5), 1262-1274 (2014).

    Product Citations

    Vandeputte, M.M., Walton, S.E., Shuda, S.A., et al. Detection, chemical analysis, and pharmacological characterization of dipyanone and other new synthetic opioids related to prescription drugs. Anal. Bioanal. Chem. (2023).