For immunochemical detection of ICOS
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ICOS/CD278 (C-Term) Rabbit Monoclonal Antibody (RM417)

Item No. 32338

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Activation-inducible Lymphocyte Immunomediatory Molecule
  • Inducible T cell Co-Stimulator
Immunogen
Peptide from the C-terminal region of human ICOS
Clone Designation
RM417
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC
Cross Reactivity
(+) ICOS
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

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    Product Description

    Inducible T cell co-stimulator (ICOS), also known as CD278, is a glycoprotein and member of the CD28/B7 family of co-stimulatory receptors that promotes T cell activation.1 It exists as a membrane-bound disulfide-linked homodimer and contains a leader peptide, an extracellular domain that interacts with ICOS ligand (ICOSL), and a cytoplasmic tail that mediates association with PI3K and is critical for T cell activation.1,2 ICOS is expressed on activated CD4+ and CD8+ T cells following T cell receptor crosslinking and/or co-stimulation by CD28.1 ICOS co-stimulation of T cells induces production of IL-4, IL-5, IL-6, IFN-γ (Item Nos. 32008 | 32078), TNF-α (Item Nos. 32020 | 32069), and GM-CSF (Item Nos. 32044 | 32079), but not IL-2, and superinduces production of IL-10, as well as prevents T cell apoptosis.2 Human melanoma cells express ICOSL and promote the expansion of ICOS+ IL-10-secreting regulatory T cells, which is positively correlated with unfavorable clinical outcomes.3 Administration of an anti-ICOS monoclonal antibody ameliorates mucosal inflammation and damage in a mouse model of T helper cell-induced chronic colitis.4 Cayman’s ICOS/CD278 (C-Term) Rabbit Monoclonal Antibody (RM417) can be used for immunohistochemistry (IHC) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wikenheiser, D.J., and Stumhofer, J.S. ICOS Co-Stimulation: Friend or Foe? Front. Immunol. 7, 304 (2016).

    2. Beier, K.C., Hutloff, A., Dittrich, A.M., et al. Induction, binding specificity and function of human ICOS. Eur. J. Immunol. 30(12), 3707-3717 (2000).

    3. Amatore, F., Gorvel, L., and Olive, D. Inducible co-stimulator (ICOS) as a potential therapeutic target for anti-cancer therapy. Expert Opin. Ther. Targets 22(4), 343-351 (2018).

    4. Kanai, T., Totsuka, T., Tezuka, K., et al. ICOS costimulation in inflammatory bowel disease. J. Gastroenterol. 37(Suppl 14), 78-81 (2002).