A metabolite of scopolamine
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Parent Compound(s)
40307Scopolamine
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Scopine (hydrochloride)

Item No. 27052

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1α,2β,4β,5α,7β)-9-methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-ol, monohydrochloride
CAS Number
85700-55-6
Molecular Formula
C8H13NO2 • HCl
Formula Weight
191.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
203 nm
SMILES
O[C@H]1C[C@H](N2C)[C@@H]3O[C@@H]3[C@H]2C1.Cl
InChi Code
InChI=1S/C8H13NO2.ClH/c1-9-5-2-4(10)3-6(9)8-7(5)11-8;/h4-8,10H,2-3H2,1H3;1H/t4-,5-,6+,7-,8+;
InChi Key
BBBRAOXIMQHVCR-YSJWXMLMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $90

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    500 mg

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    1 g

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Scopine is an active metabolite of the muscarinic acetylcholine receptor (mAChR) antagonist scopolamine (Item No. 40307).1 Scopine binds to muscarinic acetylcholine receptors with an IC50 value of 3 µM and is selective for muscarinic acetylcholine receptors over nicotinic acetylcholine receptors (IC50 = >500 µM).2 It reduces hyperphagia induced by the antipsychotics loxapine (Item No. 20760) and chlorpromazine (Item No. 16129) in C. elegans without affecting basal feeding.3 When conjugated to chlorambucil, scopine improves the blood-brain barrier permeability of chlorambucil (Item No. 23744).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, H., Chen, Y., Du, P., et al. Liquid chromatography-electrospray ionization ion trap mass spectrometry for analysis of in vivo and in vitro metabolites of scopolamine in rats. J. Chromatogr. Sci. 46(1), 74-80 (2008).

    2. Schmeller, T., Sporer, F., Sauerwein, M., et al. Binding of tropane alkaloids to nicotinic and muscarinic acetylcholine receptors. Pharmazie 50(7), 493-495 (1995).

    3. Perez-Gomez, A., Carretero, M., Weber, N., et al. A phenotypic Caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia. Nat. Commun. 9(1), 5272 (2018).

    4. Wang, X., Li, J., Xu, C., et al. Scopine as a novel brain-targeting moiety enhances the brain uptake of chlorambucil. Bioconjug. Chem. 25(11), 2046-2054 (2014).