A flavonoid with diverse biological activities
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Ombuin

Item No. 40217

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,5-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
CAS Number
529-40-8
Synonyms
  • NSC 675952
Molecular Formula
C17H14O7
Formula Weight
330.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly SolubleDMSO: SolubleMethanol: Slightly Soluble
SMILES
O=C1C(O)=C(C2=CC=C(OC)C(O)=C2)OC3=CC(OC)=CC(O)=C13
InChi Code
InChI=1S/C17H14O7/c1-22-9-6-11(19)14-13(7-9)24-17(16(21)15(14)20)8-3-4-12(23-2)10(18)5-8/h3-7,18-19,21H,1-2H3
InChi Key
BWORNNDZQGOKBY-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

    $175

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    10 mg

    $324

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    25 mg

    $742

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    Cayman Chemical
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    Product Description

    Ombuin is a flavonoid that has been found in B. balsamifera and has diverse biological activities.1,2,3,4 It is an antagonist of M1 muscarinic acetylcholine receptors (mAChRs; Ki = 42 µM in CHO-K1 cells expressing the human receptor).2 Ombuin is cytotoxic to HepG2 hepatocellular carcinoma cells (IC50 = 1.5 µg/ml).3 In vivo, ombuin (40 mg/kg per day) reduces blood urea and glucose levels, urinary volume and protein levels, serum creatinine levels, renal fibrosis levels, and body weight in a rat model of diabetic nephropathy induced by streptozotocin (STZ; Item No. 13104).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nessa, F., Ismail, Z., Mohamed, N., et al. Free radical-scavenging activity of organic extracts and of pure flavonoids of Blumea balsamifera DC leaves. Food Chem. 88(2), 243-252 (2004).

    2. Swaminathan, M., Chee, C.F., Chin, S.P., et al. Flavonoids with M1 muscarinic acetylcholine receptor binding activity. Molecules 19(7), 8933-8948 (2014).

    3. Huong, D.T., Luong, D.V., Thao, T.T.P., et al. A new flavone and cytotoxic activity of flavonoid constituents isolated from Miliusa balansae (Annonaceae). Pharmazie 60(8), 627-629 (2005).

    4. Liu, B., Deng, C., and Tan, P. Ombuin ameliorates diabetic nephropathy in rats by anti-inflammation and antifibrosis involving Notch 1 and PPAR γ signaling pathways. Drug Dev. Res. 83(6), 1270-1280 (2022).