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Bioactive Lipids Regulate Platelet Activation and Aggregation
Article from 2024-05-08
Platelets play a critical role in maintaining hemostasis and minimizing blood loss following vascular injury. However, they also have roles in pathological conditions including cerebral thrombosis, myocardial infarction, cancer, inflammation, and atherosclerosis. In this article, we will discuss the roles of thromboxanes, prostaglandins, and their receptors in the regulation of platelet activation and aggregation
TNF-α-Targeted Therapies in Alzheimer’s Disease
Article from 2024-01-17
It is estimated that 99% of drugs in clinical trials for the treatment of Alzheimer’s disease fail. Therapies that explore the connection between neuroinflammation and Alzheimer’s disease may be a promising new approach for novel treatment strategies.
Cayman LipiDOT Strips™ for the Rapid Screening of Protein-Lipid Interactions
Article from 2023-09-11
Our new Cayman LipiDOT Strips™ are a simple tool for the rapid identification of protein-lipid interactions. Researchers can screen a protein of interest against 22 biologically relevant lipids in one assay in a single day at a lower price compared with existing commercial options.
Research Tools for Psychoactive Mushroom Components & Their Metabolites
Article from 2023-07-06
Mushrooms have been used in medicinal and spiritual practices in Indigenous cultures around the world for several millennia. The two most studied genera include Psilocybe and Amanita. Because of renewed interest in entheogenic plant molecules as therapeutics, there is a large body of research building around the psychedelic effects of alkaloids found in these mushrooms. Cayman offers a comprehensive portfolio of products including ISO Certified Reference Materials (CRMs) for Psilocybe and Amanita mushroom components and their metabolites.
The Magic Molecules Behind Psychedelic Mushrooms: Resources for the Lab Wall Poster
Article from 2023-07-05
Discover additional resources to advance your psychedelic mushroom research here, including references used to compile the Psychedelic Mushrooms Lab Wall Poster, research tools for psychoactive mushrooms, and related articles for psychedelic drug discovery. Cayman offers a comprehensive portfolio of Psilocybe and Amanita mushroom components and their metabolites.
Top 10 Most Popular Cayman ELISAs in 2022
Article from 2023-01-03
Whether you’re looking for a new angle in your 2023 research or are just curious, discover Cayman’s top 10 most popular ELISAs in 2022. Steroid hormone ELISAs populate the majority of this list, followed closely by ELISAs for lipid metabolites and cyclic nucleotide second messengers.
Three Strategies to Target Actin and Myosin
Three Strategies to Target Actin and Myosin
Article from 2022-05-04
Actin and myosin are responsible for many forms of cell movement, including muscle contraction and cytoskeletal rearrangement. These processes are the basis for countless more physiological and pathological functions. Thus, targeting actin and myosin holds promise for the treatment of many diseases.
In It for the Long Haul: Research Tools for Long COVID Syndrome
Article from 2021-07-20
Cayman is poised to supply research tools to support scientists addressing the symptoms and examining the causes of Long COVID. A road map for treatment options is being drawn from other conditions with overlapping symptoms that can arise suddenly post viral infection.
Fluorescent BODIPY-Labeled Ganglioside GM1
Article from 2021-07-07
Understanding ganglioside metabolism and biological function has been made possible in part by using labeled derivatives that can be incorporated into cultured cells and artificial membranes. This includes studies of their distribution in membranes and interactions with neighboring cells as well as investigation of their metabolic fate and intracellular trafficking.
Cayman Compound Libraries
Cayman Compound Libraries
Article from 2021-06-18
Cayman offers a unique set of compound libraries, rich in biologically active molecules, useful for screening and hit seeking for diverse therapeutic targets. The content of each library is carefully selected from the large collection of small molecules in the Cayman catalog.
Growth Factor Receptors in Cancer
Growth Factor Receptors in Cancer
Article from 2021-04-01
Growth factor signaling regulates numerous cellular processes, including differentiation, survival, migration, and proliferation. Alterations to growth factor signaling pathways contribute to cancer initiation, progression, angiogenesis, and metastasis. Several FDA-approved cancer therapeutics modulate growth factor signaling by inhibiting the activity of growth factor receptors.
Toll-like Receptors: Immune Signaling Sentinels
Article from 2021-03-18
Toll-like receptors (TLRs) are important innate immune proteins responsible for the identification of invading pathogens. They are pattern recognition receptors (PRRs) capable of recognizing specific pathogen-associated molecular patterns (PAMPs) and also recognize damage-associated molecular patterns (DAMPs) from tissue injury or cell death.
Methods for Detecting Kinase Activity
Article from 2021-03-08
Keen interest has been placed in developing compounds to control kinase activity and assays to detect kinase activity and their subsequent modulation by inhibitory compounds. Here we provide an overview of the methodologies available from Cayman to assess kinase activity.
Deorphanized GPR75 Adopted by 20-HETE
Article from 2021-02-22
20-HETE, a member of the CYP450-derived eicosanoids, acts through GPR75 to elicit vascular effects. This pathway provides a new avenue for the discovery of molecules that could interfere with the hypertensive, inflammatory, or cancer-promoting actions of 20-HETE.
Tools to Study Eicosanoid GPCR Signaling
Article from 2021-02-22
Cayman offers an extensive library of agonists, antagonists, assays, and antibodies to study the function of Eicosanoid GPCRs. Explore the research products associated with each distinct signaling pathway.
Developing Biomarkers to Predict COVID-19 Disease Severity
Article from 2021-02-03
Cayman’s Lipidomics Services team use their targeted eicosanoid and oxylipin panels to help researchers at the University of Rochester detect biomarkers of inflammation in COVID-19.
How Do Antibiotics Work?
Article from 2021-01-28
Antibiotics combat bacterial infections by either killing, lysing, or stalling the growth of microbes. Learn about the six major targets that antibiotics attack as well as features that are exploited in cell culture systems and other research applications to control certain cellular functions.
PANoptosis: An Inflammatory Programmed Cell Death Pathway
Article from 2021-01-22
PANoptosis, which involves the collective activation of pyroptosis, apoptosis, and necroptosis, is a newly described inflammatory programmed cell death pathway induced by bacterial and viral pathogens. Learn about its mechanism and regulation, as well as recent research suggesting a role for PANoptosis in COVID-19-associated inflammation.
Remdesivir: The First FDA-Approved Treatment for COVID-19
Article from 2020-12-04
In an encouraging step in the fight against COVID-19, the antiviral remdesivir is the first drug approved by the FDA for the treatment of this disease. Here we discuss the metabolism of remdesivir to a nucleoside triphosphate that can be mistakenly incorporated into the genome of RNA-based viruses by the viral replication machinery, confounding the viral replication process.
Plasmalogens: Antioxidant, Signaling, and Structural Roles
Plasmalogens: Antioxidant, Signaling, and Structural Roles
Article from 2020-09-08
Plasmalogens are membrane glycerophospholipids that contain an acid labile vinyl ether group at the sn-1 position of the glycerol backbone, a fatty acid at the sn-2 position, and a polar head group at the sn-3 position.
Cayman’s 2020 Women in Research Grant Recipients
Cayman’s 2020 Women in Research Grant Recipients
Article from 2020-07-22
To commemorate Women’s History Month and further our mission of helping make research possible, Cayman awarded forty $1,000 research grants. Here are the researchers Cayman is proud to be supporting.
Calming The Cytokine Storm Through Kinase Inhibition
Article from 2020-07-10
Recent evidence suggests that inhibition of kinases involved in the regulation of immune signaling and the inflammatory response may present a viable strategy for the management of excessive inflammation in patients with COVID-19.
Vaccine Development for Emerging Infectious Disease
Article from 2020-04-13
The pandemic caused by the unexpected emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, has prompted an urgent need to develop a vaccine against this infectious disease.
Cyclic Dinucleotides: Ubiquitous Cellular Messengers
Article from 2020-04-08
Cyclic dinucleotides (CDNs) serve signaling functions in all domains of life. In eukaryotes, CDN signaling systems provide a means to sense and respond to pathogen infection by detecting foreign nucleic acid species.
Using Existing Therapeutics Against SARS-CoV-2
Article from 2020-03-30
Existing FDA-approved drugs that have a known favorable safety profile are being examined for strategies to manage SARS-CoV-2 infection and fast-track a COVID-19 treatment plan. Drugs already on the market are being evaluated based on their ability to inhibit any proteins essential for virus-receptor interaction and/or viral life cycle.
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Cayman Chemical1180 East Ellsworth RoadAnn Arbor, Michigan 48108 USAToll Free: (800) 364-9897(USA and Canada only)Fax: (734) 971-3640
