Filter by Type

Article (32)

Filter by Categories

Cancer (8)
Cardiovascular System (5)
Cell Biology (7)
Endocrinology & Metabolism (5)
Epigenetics, Transcription, & Translation (2)
Forensic Chemistry & Toxicology (3)
Immunology & Inflammation (10)
Infectious Disease (6)
Lipid Biochemistry (27)
Lipid-Based Drug Delivery (1)
Neuroscience (5)
Oxidative Stress & Reactive Species (4)
Services (16)
Toxicology (2)
Displaying 1 - 25 of 32 Results

Advancing MASLD & MASH Research: PPAR and FFAR Fatty Acid Signaling Pathways

Article from 2024-08-28

This is the third article in our series on Advancing MASLD and MASH Research with Tools and Strategies for Metabolic Dysfunction in Steatotic Liver Disease. 

In this article, we cover aberrant lipid homeostasis as a underlying factor in the development of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) and how to regulate fatty acid signaling pathways in MASLD and MASH.

Advancing MASLD & MASH Research: The Roles of LXRs, FXRs, and GP-BAR1 in Metabolic Regulation

Article from 2024-08-28

This is the third article in our series on Advancing MASLD and MASH Research with Tools and Strategies for Metabolic Dysfunction in Steatotic Liver Disease. 

Here, we explore how metabolic regulation through liver X receptors (LXRs), farnesoid X receptors (FXRs), and G protein-coupled bile acid receptors (GP-BARs) can be used to target cholesterol, bile acid, and glucose homeostasis in metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH).

Five Ways Our Scientists Helped Make Research Possible​

Article from 2024-07-26

Cayman is more than a supplier of products and services for life science research. We are scientists. We work collaboratively with fellow scientists in academia, biotechnology, and pharmaceutical industries, combining our expertise to solve complex problems and advancing our collective understanding in our shared field of study. 

Discover the ways that Cayman scientists helped make research possible for these scientists in these papers published in 2024.

Highlights from Our Discoveries in 2024: A Review of Scientific Posters

Article from 2024-07-10

Our scientists showcased their research findings during the vibrant spring 2024 conference season, providing an invaluable opportunity to exchange ideas and establish new collaborations with the broader scientific community.

Explore the products and services from Cayman that supported our findings and discover how these tools can help make your research possible.

Key Takeaways from Discoveries We Made in 2023: A Review of Scientific Posters

Article from 2023-12-01

Cayman scientists regularly present discoveries from our ongoing research and development activities with the larger research community at scientific conferences. Explore the methods and tools we used to make our discoveries and see how they can be used to support your research in our 2023 scientific poster recap.

Crosstalk in the Arachidonic Acid Cascade

Article from 2022-06-23

Arachidonic acid (AA) undergoes enzymatic and non-enzymatic oxidation to produce an array of lipid metabolites with central and diverse roles in health and disease. Understanding the extensive crosstalk that exists within the network of enzymes and metabolites in the AA cascade is critical for finding ways to modify the formation and function of these lipid metabolites.

Neutralizing Antibody Analysis Post COVID-19 Infection or Vaccination

Article from 2021-09-08

Cayman’s Bioanalysis & Assay Development Services partnered with GenScript to examine the onset and durability of the COVID-19 vaccine-induced neutralizing antibody response.

Sphingolipid Solubilization, Isolation, Analysis, and Storage Advice

Article from 2021-03-19

Learn about sphingolipid solubility, isolation, related fatty acid analysis by GC/FID, and storage and handling to achieve the best results possible with our sphingolipid products.

Detecting Neutralizing Antibody Responses to COVID-19

Article from 2021-02-09

Cayman’s Bioanalysis & Assay Development Services help validate an assay that allows direct assessment of the capacity of inhibitory immunoglobins or synthetic compounds to block the binding of spike protein to ACE2.

Developing Biomarkers to Predict COVID-19 Disease Severity

Article from 2021-02-03

Cayman’s Lipidomics Services team use their targeted eicosanoid and oxylipin panels to help researchers at the University of Rochester detect biomarkers of inflammation in COVID-19.

Lipid Nomenclature

Article from 2021-01-20

Cayman’s naming system for prostaglandins is taken from the literature, which often uses the trivial names and historically accepted conventions for the description of substituents (e.g., prostaglandins and their analogs).

​Analytical Techniques

Article from 2021-01-20

The basics of ELISA, GC-MS, and LC-MS/MS are described as approaches to quantify bioactive lipids in cells and biological samples. Each method offers advantages and pitfalls that must be considered when determining with method is right for your requirements.

​Plasmalogens: Antioxidant, Signaling, and Structural Roles

Article from 2020-09-08

Plasmalogens are membrane glycerophospholipids that contain an acid labile vinyl ether group at the sn-1 position of the glycerol backbone, a fatty acid at the sn-2 position, and a polar head group at the sn-3 position.

​Cayman’s 2020 Women in Research Grant Recipients

Article from 2020-07-22

To commemorate Women’s History Month and further our mission of helping make research possible, Cayman awarded forty $1,000 research grants. Here are the researchers Cayman is proud to be supporting.

Continuing to Help Make Research Possible

Article from 2020-04-07

As a business that provides the products to support essential research for human health and well-being, Cayman has been operational throughout the COVID-19 pandemic. We enacted policies to protect our employees and our local community while continuing to provide the kits, antibodies, proteins, biochemicals, and contract services you depend on to keep your research going.

We understand how important your work is. Here are a couple things we offer to help make your research possible.

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

Article from 2020-02-26

Cayman scientists perform a redox-targeted lipidomics analysis of ferroptosis-sensitive cancer cells to map the activity of a newly identified enzyme in the lipid peroxidation step in ferroptosis.

Meet the Expert: Biomarker Development

Article from 2020-02-26

Meet Beth Hurst, Ph.D., manager of the Biomarker Development Services Group, and learn about the work that is ongoing in Cayman's Biomarker Development Group, which offers a diverse suite of services in assay development and biomarker profiling. 

Eicosanoid Analysis: Thoughts on Internal Standards and Reference Standards

Article from 2019-10-09

Over the past 50 years, mass spectrometry has emerged as the gold standard for the quantitative analysis of bioactive lipids, including metabolites of arachidonic acid. Significant advances in mass analyzer hardware and ionization processes have brought this technique to the forefront. Important changes have occurred just in the past 25 years, with the emergence of electrospray ionization (ESI) and remarkable developments in tandem mass spectrometry, including tandem quadrupole mass spectrometer systems and ion trap-based mass analyzers.

Specialized Pro-Resolving Mediators and Eicosanoids: A Solid-Phase Extraction Protocol from Tissues and Biological Fluids

Article from 2019-10-09

Following infection and/or injury, the acute inflammatory response is a protective mechanism initiated by the host. Ideally, complete resolution of inflammation allows a return to homeostasis. Lipid mediators have crucial roles in both initiation of inflammation and its timely resolution. The cardinal signs of inflammation are initiated by specific eicosanoids, e.g., prostaglandins and leukotrienes, stimulating responses such as neutrophil recruitment. As a reflection of the neutrophil-monocyte sequence, a lipid mediator class switching occurs with the biosynthesis of specialized pro-resolving mediators (SPMs).

Explore Our Large Selection of Lipids

Article from 2019-06-20

Cayman Chemical has nearly four decades of expertise in the isolation, synthesis, and analysis of bioactive lipids. We offer high-purity fatty acids, glycerolipids, glycerophospholipids, sphingolipids, sterol lipids, and prenol lipids to be used as research standards in biotechnology and pharmaceutical pursuits. We also supply corresponding isotopically labeled standards, LC-MS mixtures, MaxSpec® analytical standards, ELISAs, derivatization kits, labeling & detection probes, and Lipidomics Services to enable your method development, biomarker discovery, and quantitative detection. Use the links below, based upon LIPID MAPS® classifications, to browse our extensive and continuously expanding line of lipid products.

Stable Isotope-Labeled Sphingolipids as Highly Specific Mass Spectrometry Standards

Article from 2019-06-03

Appropriate sphingolipidomic internal standards include sphingolipids that are modified on either the oligosaccharide head, ceramide acyl chain, or the sphingosine backbone. One of the most preferred internal standards for lipidomic studies are stable isotope-labeled standards.

Revising the structure of a new eicosanoid from human platelets to 8,9-11,12-diepoxy-13-hydroxy-eicosadienoic acid

Article from 2019-05-15

Eicosanoids are critical mediators of fever, pain and inflammation generated by immune and tissue cells. We recently described a new bioactive eicosanoid generated by cyclooxygenase-1 (COX-1) turnover during platelet activation that can stimulate human neutrophil integrin expression. On the basis of mass spectrometry (MS/MS and MS3), stable isotope labeling and GC/MS analysis, we previously proposed a structure of 8-hydroxy-9,11-dioxolane eicosatetraenoic acid (DXA3). Here, we achieved enzymatic synthesis and 1H-NMR characterization of this compound with results in conflict with the previously proposed structural assignment.

Lipidomics

Article from 2019-05-09

With Cayman Contract Services, your lipidomics study is in the hands of scientists who have several decades of collective experience in lipid synthesis, purification, and characterization. Cayman’s lipid analysis laboratories are equipped with state-of-the-art chromatography/mass spectrometry systems and data analysis software, enabling us to offer targeted and untargeted lipidomics services to meet your specific project needs.

Plasma oxylipins respond in a linear dose-response manner with increased intake of EPA and DHA: results from a randomized controlled trial in healthy humans

Article from 2019-05-06

Some intervention studies have demonstrated that eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) increase systemic concentrations of n-3 PUFA-derived oxylipins and moderately decrease arachidonic acid-derived oxylipins. There is no information on the dose-response of oxylipin concentrations after n-3 PUFA intake. The aim of this study was to quantify oxylipins in human plasma samples from an intervention study in which participants were randomly assigned to different daily intakes of EPA and DHA for 12 mo.

CD8+ T cells regulate tumor ferroptosis during cancer immunotherapy

Article from 2019-05-06

Here we show that immunotherapy-activated CD8+ T cells enhance ferroptosis-specific lipid peroxidation in tumour cells, and that increased ferroptosis contributes to the anti-tumour efficacy of immunotherapy. Mechanistically, interferon gamma (IFNγ) released from CD8+ T cells downregulates the expression of SLC3A2 and SLC7A11, two subunits of the glutamate-cystine antiporter system xc−, impairs the uptake of cystine by tumour cells, and as a consequence, promotes tumour cell lipid peroxidation and ferroptosis.

Displaying 1 - 25 of 32 Results