An mRNA for the expression of Cre
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Product Type

Lipid Nanoparticles (LNPs)
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Cre mRNA (Cap-1; m1Ψ)

Item No. 41963

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • EZ Cap™ Cre mRNA (N1-Methylpseudouridine)
Formulation
1 mM Sodium citrate, pH 6.4
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    100 µg

    $204

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    $1,018

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    Cayman Chemical
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    Product Description

    Cre mRNA (Cap-1; m1Ψ) encodes Cre, a bacteriophage tyrosine recombinase that catalyzes homologous recombination between two loxP sites in DNA.1 It is capped using a co-transcriptional capping method, resulting in the naturally occurring Cap 1 structure with high capping efficiency. Cre mRNA is also polyadenylated and modified with N1-methylpseudouridine (m1Ψ) to reduce the host cell immune response and enhance mRNA stability. Encapsulation of Cre mRNA (Cap-1; m1Ψ) in lipid nanoparticles (LNPs) can be used for mRNA delivery and expression of Cre in vitro or in vivo.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rajewsky, K., Gu, H., Kühn, R., et al. Conditional gene targeting. J. Clin. Invest. 98(3), 600-603 (1996).

    2. Tanaka, H., Hagiwara, S., Shirane, D., et al. Ready-to-use-type lyophilized lipid nanoparticle formulation for the postencapsulation of messenger RNA. ACS Nano 17(3), 2588-2601 (2023).