mCherry mRNA (Cap-1; m1Ψ)

mCherry mRNA (Cap-1; m1Ψ) encodes mCherry, a red fluorescent protein and derivative of Discosoma red fluorescent protein (DsRed) that displays excitation and emission maxima of 587 and 610 nm, respectively.¹ It is capped using a co-transcriptional capping method, resulting in the naturally occurring Cap 1 structure with high capping efficiency. mCherry mRNA is also polyadenylated and modified with N¹-methylpseudouridine (m1Ψ) to reduce the host cell immune response and enhance mRNA stability. Encapsulation of mCherry mRNA (Cap-1; m1Ψ) in lipid nanoparticles (LNPs) can be used for mRNA delivery and expression of mCherry fluorescent protein in vitro or in vivo.²

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1. Shaner, N.C., Campbell, R.E., Steinbach, P.A., et al. Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nat. Biotechnol. 22(12), 1567-1572 (2004).

2. Hamilton, A.G., Swingle, K.L., Joseph, R.A., et al. Ionizable lipid nanoparticles with integrated immune checkpoint inhibition for mRNA CAR T cell engineering. Adv. Healthc. Mater. 12(30), e2301515 (2023).