An mRNA for the expression of luciferase
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Product Categories

Product Type

Lipid Nanoparticles (LNPs)
Cargos

Application

Chemiluminescence

Firefly Luciferase mRNA (Cap-1; m1Ψ)

Item No. 43677

Product Insert (PDF)
Technical Information
Emission
~560 nm
Formulation
1 mM Sodium citrate, pH 6.4
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    100 µg

    $504

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    1 mg

    $1,764

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    Cayman Chemical
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    Product Description

    Firefly luciferase mRNA (Cap-1; m1Ψ) encodes luciferase, a protein originally isolated from the firefly P. pyralis, that catalyzes the ATP-dependent oxidation of the molecule luciferin resulting in chemiluminescence at a wavelength of approximately 560 nm.1,2 It is capped using a co-transcriptional capping method, resulting in the naturally occurring Cap-1 structure with high capping efficiency. Firefly luciferase mRNA is also polyadenylated and modified with N1-methylpseudouridine (m1Ψ) to reduce the host cell immune response and enhance mRNA stability. Encapsulation of firefly luciferase mRNA (Cap-1; m1Ψ) in lipid nanoparticles (LNPs) can be used for mRNA delivery and expression of luciferase.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Baldwin, T.O. Firefly luciferase: The structure is known, but the mystery remains. Structure 4(3), 223-228 (1996).

    2. Zhang, G., Gurtu, V., and Kain, S.R. An enhanced green fluorescent protein allows sensitive detection of gene transfer in mammalian cells. Biochem. Biophys. Res. Commun. 227(3), 707-711 (1996).