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Displaying 1 - 25 of 25 Results

Natural Products for Drug Discovery in Modern Medicine

Article from 2025-03-06

Natural products have been a historically invaluable source of bioactive compounds with well-recognized potential therapeutic uses. Today, they continue to represent important sources for new drugs. 

High-throughput screening is used extensively in drug discovery to rapidly identify candidate hit compounds for hit-to-lead development. Cayman’s Natural Product Screening Library contains over 1,600 chemically, structurally, and biologically diverse natural products to support drug discovery efforts.

We Support Accurate Analysis Through High-Quality Reference Standards

Article from 2025-01-07

Cayman supplies reference standards for a wide range of testing and research applications, including forensic science, clinical analysis, toxicology, pharmacology, and natural product testing. 

We offer our products as analytical standards, reference materials (RMs), and certified reference materials (CRMs) to cover individual analytical testing needs and laboratory requirements.

The Latest Research Insights on Hexahydrocannabinol Metabolism

Article from 2024-07-08

Hexahydrocannabinols (HHCs) are semi-synthetic cannabinoids that are structurally similar to Δ9-THC. HHCs are often marketed as “legal” alternatives to Δ9-THC, reportedly producing similar psychoactive effects. Although the pharmacological activity and metabolism of Δ9-THC has been extensively characterized, understanding the human metabolism of HHCs is developing. Elucidating the full metabolic profile of HHCs is critical to understanding the full pharmacology of these novel substances.

Pharmacology of Hexahydrocannabinols and Other Semi-Synthetic Cannabinoids

Article from 2024-06-26

Semi-synthetic cannabinoids rapidly emerged in the United States in response to legislative reforms that loosened Cannabis restrictions. Often marketed as “legal” alternatives to Δ9-THC, semi-synthetic cannabinoids have been widely sought after for both medicinal and recreational purposes. In this article, we cover what is known about the pharmacology of semi-synthetic cannabinoids and highlight critical areas for continued research in this field.

CABRI Awards $40,000 in Fellowships to Ten Undergraduate Researchers

Press Release from 2022-12-12

Cayman joins the Cayman Biomedical Research Institute (CABRI) in recognizing the ten undergraduate students who have been awarded fellowships by CABRI for the 2022-2023 academic year. The fellowship awards are given to talented undergraduates that are pursuing a research project of their own under the guidance of a faculty mentor.

Latest NPS Reported as European Drug Trends in 2020

Article from 2021-07-09

The European Monitoring Centre for Drug and Drug Addiction (EMCDDA) released its annual European Drug Report Trends and Development on 9th June 2021. The report provides a mixture of data from 2019 and 2020, and for the first time excludes data from the United Kingdom since leaving the EU.

Meet the Experts: Quality Control

Article from 2021-06-09

Meet Libby Perry, Tim Schrot, Matt Webb, Rich Bartell, Roxanne Franckowski, and Paul Kennedy who head Cayman's quality control testing teams in our Chemistry, Biochemistry, GMP, ISO Quality, and Analytical Services departments.

Degradants Formed During Phytocannabinoid Processing

Article from 2020-11-02

During various stages of plant processing, many phytocannabinoids may undergo degradation through isomerization and/or oxidation. Formation of these byproducts can complicate the isolation of the desired phytocannabinoids and also degrade pure isolates over time if they are improperly stored.

​Cannabis: Our Key to the Endocannabinoid System

Article from 2020-10-30

Although today we still know very little about Cannabis, its powers come from the ability of the chemical constituents to activate and affect the endocannabinoid system (ECS), a homeostatic regulatory system ubiquitous to every living creature on the planet. 

​International Regulation and Control of Hemp and Cannabinoids

Article from 2020-10-29

For a plant that has been used for millennia, controls on the supply of psychoactive and non-psychoactive components extracted from Cannabis are relatively recent. We describe the current regulatory landscape with a focus on how it pertains to the manufacture and distribution of analytical reference standards for phytocannabinoids.

Drugs Used in Conflict and Wars, Part 3 : Opium

Article from 2020-09-17

From Homer and Hesiod in Ancient Greece to current-day music, it is not hard to find references to opiates and opioids in popular culture. Over time, opiates and opioids have become one of the most studied groups of drugs.

​Cannabinoid Signaling: Insights to Future Pharmacotherapeutic Development

Article from 2020-09-03

​Active compounds found in plants of the Cannabis genus as well as endogenous analogs of these substances, and a myriad of synthetic analogs can influence a wide range of biological processes by engaging G protein-coupled receptors (GPCRs) of the endocannabinoid system.

​Certified Reference Materials for the Cannabis Industry: Solving the Production Puzzle

Article from 2020-07-15

This article outlines several production steps Cayman considers when creating a CRM to address questions frequently heard from our customers about how compounds are selected to be made into CRMs and how long it takes to produce them. 

This article was first published in the July/August issue of Terpenes and Testing.

Why Does Alkyl Chain Length Matter?

Article from 2020-04-13

Alkyl side chain length directly correlates with receptor binding affinity at human cannabinoid receptors. Novel four-carbon and seven-carbon homologs of cannabidiol (CBD) and Δ9-THC are reported to have binding activity more potent than that of Δ9-THC.

Analytical Data Confidence is Highest with Commercially Prepared CRM Mixtures

Article from 2019-08-28

High-quality reference materials with established metrological traceability are an essential element for measurement accuracy during routine analytical checks as well as for Cannabis product quality testing and profiling. We compare two different methods using certified reference materials (CRMs) to generate a standard for the quantitation of ten prevalent phytocannabinoids against a calibration curve to show that pre-made multi-component CRM mixtures improve quantitation accuracy.

Precision Cannabis Testing

Article from 2019-08-08

As the cannabis industry is now a multibillion-dollar global market and will only continue to grow as more jurisdictions legalize medicinal and/or recreational cannabis products, consumer safety is of the utmost importance. To ensure product safety, as with any product intended for human use, various governments, regulatory bodies, and stakeholders are working towards standardization within the industry. This is best accomplished by quality control testing of cannabis, including potency determination.

Stimulant Use and Abuse: Amphetamines

Article from 2019-07-17

Stimulants belong to a diverse group of psychoactive drugs whose function exerts a constant contribution to hyperactivity and impulse control. From caffeine and nicotine to cocaine and amphetamines, each vary widely in how amply they accelerate body functions, how they are used, and their legal status. Illegal stimulant derivatives including amphetamines, arylcyclohexylamines, cathinones, cocaine/tropanes, phenethylamines, and piperazines are among the most widely abused across the US and Europe.

Cannabinoid Receptor Wall Poster References

Article from 2018-03-09

​Review the list of references cited on Cayman's Cannabinoid Receptors wall poster.

​ToxBox®: Plate-Based Tool for Cannabis​ Testing by LC-MS/MS

Press Release from 2017-06-16

​Cayman, in collaboration with PinPoint Testing, LLC​ and Biotage​, has introduced the ToxBox® THC/THC Metabolite Pack, an all-inclusive tool to detect THC, the primary active constituent in Cannabis, and its main metabolites.

​Faster Quantitation Workflow with 10-analyte Phytocannabinoid Mixture​

Article from 2017-06-09

​Cayman has released Phytocannabinoid Mixture 10 (CRM), a quantitative, multi-analyte mixture for use as an analytical standard in the simultaneous detection of the ten most prevalent phytocannabinoids found in Cannabis plants: cannabidivarin (CBDV), cannabidiolic acid (CBDA), cannabigerolic acid (CBGA), cannabigerol (CBG), cannabidiol (CBD), cannabinol (CBN), tetrahydrocannabinolic acid A (THCA-A), Δ9-tetrahydrocannabinol (Δ9-THC), Δ8-tetrahydrocannabinol (Δ8-THC), and (±)-cannabichromene (CBC).

​On a New Cannabinoid Classification System: A Sight on the Illegal Market of Novel Psychoactive Substances

Article from 2016-09-29

Synthetic cannabinoids are one of the most rapidly expanding classes of novel psychoactive substances found in illegal markets. These substances have evolved to the point that many examples no longer fit with the traditional cannabinoid classification system, where assignment of these compounds is difficult and ambiguous, leading to inconsistencies in regard to their chemical structures.

​BreviTest Awarded Grant from National Institute on Drug Abuse to Optimize Device for Rapid Cannabis Testing

Press Release from 2016-04-12

BreviTest Technologies has been awarded a $234,412 grant from the National Institute on Drug Abuse of the National Institutes of Health (NIH) to explore rapid testing for THC, the main active ingredient in cannabis.

Review of Cannabis Dosage Formulations

Article from 2015-10-01

Cannabinoid pharmaceutical preparations are available in the United States and are regulated by the Food and Drug Administration (FDA) and the Drug Enforcement Administration (DEA). However, patients and recreational users can also obtain cannabinoid-containing medications and recreational products in herbal form or in Cannabis-derived dosage formulations through dispensaries and statewide programs.

​Synthetic Cannabinoids are Recurring Chemical Threats

Article from 2015-10-01

Synthetic cannabinoids were originally designed and synthesized as molecular probes to characterize structure-activity relationships and to elucidate the biological basis and pharmacological properties of the chemical constituents in Cannabis. These efforts culminated in identification of the chemical structure of the plant’s primary psychoactive compound, Δ9-THC, and its later synthesis.

​Analysis of Synthetic Cannabinoids and Designer Drugs

Article from 2012-09-01

Designer drugs are creating opportunities. Herbal blends advertised as "100% legal" are popular with students and young adults, although the ingredients aren't listed. That creates an opportunity for companies to develop ways to accurately detect synthetic cannabinoids (CBs) and designer drugs that might be mixed with flavorings and scents in plant material. There are opportunities for manufacturers of equipment to produce instruments that can detect parent compounds and metabolites in urine, saliva, serum, or hair.

Displaying 1 - 25 of 25 Results