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Displaying 1 - 25 of 47 Results

Analytical Standards to Support the CFSRE’s Novel Psychoactive Substance Scope Recommendations: Q2 2026

Featured Article from 2026-06-26

The NPS Discovery program at the Center for Forensic Science Research & Education (CFSRE) publishes a quarterly scope recommendation to provide the latest guidance in developing an appropriate analytical scope of testing for novel psychoactive substances (NPS).

Making a Splash: Nitazenes and Orphines, the Latest Wave of Opioid NPS Webinar Highlights

Article from 2025-07-15

Nitazenes and orphines are two classes of synthetic opioids that are proliferating in illicit drug markets. Danielle St. Germaine, a synthetic organic chemist in the Forensic Chemistry Division at Cayman Chemical, discussed the history, pharmacology, naming, and fragmentation of nitazenes and provided a brief glimpse of orphines in this recent webinar. We have summarized the key insights from the webinar here.

We Support Accurate Analysis Through High-Quality Reference Standards

Article from 2025-01-07

Cayman supplies reference standards for a wide range of testing and research applications, including forensic science, clinical analysis, toxicology, pharmacology, and natural product testing. 

We offer our products as analytical standards, reference materials (RMs), and certified reference materials (CRMs) to cover individual analytical testing needs and laboratory requirements.

Some Assembly Required: Emerging Synthetic Cannabinoids Webinar Highlights

Article from 2024-11-06

Holly Pierzynski, manager of Forensic Novel Psychoactive Substance Research at Cayman Chemical, discussed several emerging synthetic cannabinoids, their precursors, synthesis, and byproducts in a recent webinar. We have summarized the takeaways from this webinar here

Five Ways Our Scientists Helped Make Research Possible​

Article from 2024-07-26

Cayman is more than a supplier of products and services for life science research. We are scientists. We work collaboratively with fellow scientists in academia, biotechnology, and pharmaceutical industries, combining our expertise to solve complex problems and advancing our collective understanding in our shared field of study. 

Discover the ways that Cayman scientists helped make research possible for these scientists in these papers published in 2024.

The Latest Research Insights on Hexahydrocannabinol Metabolism

Article from 2024-07-08

Hexahydrocannabinols (HHCs) are semi-synthetic cannabinoids that are structurally similar to Δ9-THC. HHCs are often marketed as “legal” alternatives to Δ9-THC, reportedly producing similar psychoactive effects. Although the pharmacological activity and metabolism of Δ9-THC has been extensively characterized, understanding the human metabolism of HHCs is developing. Elucidating the full metabolic profile of HHCs is critical to understanding the full pharmacology of these novel substances.

Pharmacology of Hexahydrocannabinols and Other Semi-Synthetic Cannabinoids

Article from 2024-06-26

Semi-synthetic cannabinoids rapidly emerged in the United States in response to legislative reforms that loosened Cannabis restrictions. Often marketed as “legal” alternatives to Δ9-THC, semi-synthetic cannabinoids have been widely sought after for both medicinal and recreational purposes. In this article, we cover what is known about the pharmacology of semi-synthetic cannabinoids and highlight critical areas for continued research in this field.

​FAS Kits Advance Laboratory Detection of Synthetic Opioids and Emerging Drugs of Concern, Support Overdose Crisis Countermeasures

Article from 2024-05-14

Analytical laboratories are an essential ally in the response to the overdose crisis. By equipping analytical laboratories with reference standards that provide broad coverage of emerging drugs of abuse, including synthetic opioids and novel psychoactive substances (NPS), the Fentanyl Analog Screening (FAS) Kit, FAS Kit - Emergent Panels, and FAS Kit - Emergent Drug Panels support overdose crisis countermeasures.

Designer Drug Scene Webinar Highlights

Article from 2024-03-21

Holly Pierzynski, manager of Forensic Novel Psychoactive Substance Research at Cayman Chemical, discussed new developments in several popular drug classes in a recent webinar. The webinar highlighted new analogs and the rise of synthetic precursors. We have summarized the key takeaways from the webinar here.

Xylazine-laced Fentanyl: The Deadly Combination Sweeping Across the United States

Article from 2023-04-28

The veterinary tranquilizer xylazine is sweeping across the United States at an alarming rate, and concerns over the growing number of xylazine-related overdoses have led the Biden administration to declare xylazine-laced fentanyl an emerging threat in the United States.

Comprehensive Analytical Standards Panels for the Detection of Drugs of Abuse

Article from 2023-01-17

The identification of traditional and emerging drugs of abuse is critically dependent on the availability of authentic reference standards. To help improve the access of analytical standards to laboratories performing comprehensive drug screening, Cayman now offers nine cost-effective Analytical Standards Panels that collectively provide coverage of 1,274 traditional and emerging drugs of abuse.

Crosstalk in the Arachidonic Acid Cascade

Article from 2022-06-23

Arachidonic acid (AA) undergoes enzymatic and non-enzymatic oxidation to produce an array of lipid metabolites with central and diverse roles in health and disease. Understanding the extensive crosstalk that exists within the network of enzymes and metabolites in the AA cascade is critical for finding ways to modify the formation and function of these lipid metabolites.

CB1 and CB2 Receptor Activity of OXIZID Synthetic Cannabinoids

Article from 2022-06-20

The CB1 and CB2 receptor activity of OXIZID synthetic cannabinoids has been published. This study used Cayman reference standards to determine the potency and efficacy of OXIZID synthetic cannabinoids at CB1 and CB2 receptors with in vitro assays.

Meet the Expert: Novel Psychoactive Substances

Article from 2021-09-08

Meet Cayman’s Vice President of Forensic Chemistry, Donna M. Iula, Ph.D., and learn about the work she is doing to keep abreast of the rapidly changing NPS landscape and oversee the manufacture of fit-for-purpose analytical reference standards and ISO-certified materials.

Latest NPS Reported as European Drug Trends in 2020

Article from 2021-07-09

The European Monitoring Centre for Drug and Drug Addiction (EMCDDA) released its annual European Drug Report Trends and Development on 9th June 2021. The report provides a mixture of data from 2019 and 2020, and for the first time excludes data from the United Kingdom since leaving the EU.

​Cayman Compound Libraries

Article from 2021-06-18

Cayman offers a unique set of compound libraries, rich in biologically active molecules, useful for screening and hit seeking for diverse therapeutic targets. The content of each library is carefully selected from the large collection of small molecules in the Cayman catalog.

Degradants Formed During Phytocannabinoid Processing

Article from 2020-11-02

During various stages of plant processing, many phytocannabinoids may undergo degradation through isomerization and/or oxidation. Formation of these byproducts can complicate the isolation of the desired phytocannabinoids and also degrade pure isolates over time if they are improperly stored.

​Cannabis: Our Key to the Endocannabinoid System

Article from 2020-10-30

Although today we still know very little about Cannabis, its powers come from the ability of the chemical constituents to activate and affect the endocannabinoid system (ECS), a homeostatic regulatory system ubiquitous to every living creature on the planet. 

​International Regulation and Control of Hemp and Cannabinoids

Article from 2020-10-29

For a plant that has been used for millennia, controls on the supply of psychoactive and non-psychoactive components extracted from Cannabis are relatively recent. We describe the current regulatory landscape with a focus on how it pertains to the manufacture and distribution of analytical reference standards for phytocannabinoids.

​53 NPS Reported for First Time in European Drug Report 2020: Most are Available from Cayman

Article from 2020-10-05

The European Drug Report 2020 compiled by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) was released on 22 September 2020. While the more traditional drugs of abuse continue to dominate, 53 new materials have been reported throughout the year.

​Plasmalogens: Antioxidant, Signaling, and Structural Roles

Article from 2020-09-08

Plasmalogens are membrane glycerophospholipids that contain an acid labile vinyl ether group at the sn-1 position of the glycerol backbone, a fatty acid at the sn-2 position, and a polar head group at the sn-3 position.

​Cannabinoid Signaling: Insights to Future Pharmacotherapeutic Development

Article from 2020-09-03

​Active compounds found in plants of the Cannabis genus as well as endogenous analogs of these substances, and a myriad of synthetic analogs can influence a wide range of biological processes by engaging G protein-coupled receptors (GPCRs) of the endocannabinoid system.

​Cayman’s 2020 Women in Research Grant Recipients

Article from 2020-07-22

To commemorate Women’s History Month and further our mission of helping make research possible, Cayman awarded forty $1,000 research grants. Here are the researchers Cayman is proud to be supporting.

​Certified Reference Materials for the Cannabis Industry: Solving the Production Puzzle

Article from 2020-07-15

This article outlines several production steps Cayman considers when creating a CRM to address questions frequently heard from our customers about how compounds are selected to be made into CRMs and how long it takes to produce them. 

This article was first published in the July/August issue of Terpenes and Testing.

Top NPS Identified in Europe in 2019 are Available from Cayman

Article from 2020-04-17

The most recent EMCDDA Drug Report in June 2019 updated the well-established graph showing the number and types of NPS appearing annually between 2005 and 2018.

Displaying 1 - 25 of 47 Results